SomnetX simulates how an inhaled aerosol travels through the human airway and reports how much of each dose lands in every region, from the mouth–throat to the bronchi. Answers in days, before you commit to imaging or clinical studies.
mouthpiece
trachea
carina
bronchial tree
Pharmacopeial tests push the aerosol through a right-angle metal throat at a constant flow. For many products they underpredict what the mouth and throat catch, and so overestimate the lung dose. We run the same aerosol through a human airway at the flow rates your patients actually reach.
Drug mass by particle size band. No anatomy, one fixed flow.
Dose by airway region, for each flow rate and particle size you test.
Both panels are illustrative layouts, not measured values.
The EU exemption for pMDI propellants shrinks from 2027 and ends in 2030. 44% of pMDIs sold have no declared low-GWP plan.
Compare regional deposition of your current and new-propellant formulations from your own APSD data, before you commit to bridging studies.
Source: Inhalation, Dec 2025Industry estimate for a single clinical-endpoint bioequivalence study with more than 900 patients.
Regional deposition evidence to support an in vitro and modelling route, in line with FDA's work on model master files.
Source: ONdrugDelivery (Nanopharm), 2020of hospitalised COPD patients misused at least one inhaler, including breaths too weak for the device.
Test weak, typical and strong inhalation flow rates in different airway geometries without recruiting a single patient.
Source: Grandmaison et al., Chronic Obstr Pulm Dis, 2024Simulation does not replace your clinical programme. It tells you which formulation, device or breathing condition deserves the expensive steps, and gives reviewers a mechanism behind your data.
Step heights indicate relative cost and effort, not exact figures.
Before we model your device, the solver is tested on the ERCOFTAC realistic-airway benchmark, where PIV measurements and published LES are available.
Mean in-plane velocity across each PIV line, normalised by the tracheal bulk velocity. Real simulation output, shown for all six stations without smoothing.
You send the airway and the question. One automated pipeline does the rest.
The airway is filled with cubes automatically. No days of manual mesh repair.
A full mouth-to-bronchi airway at 0.5 mm in about 7.4 hours, measured on our own run.
Two flow rates by three particle sizes, the scope of one pilot, run as a single batch.
On the roadmap automatic CT segmentation (today we start from your STL or a segmented scan) · breathing-cycle inflow · nasal and upper airways, including sleep-disordered breathing
We agree the device flow profile, particle size distribution and the questions the report must answer.
→ one-page case definitionA validated reference airway, or your CT-derived airway after surface checks and region labelling.
→ labelled airway modelAirflow to statistical steady state, then particle injection across your size bins on GPU.
→ flow and particle dataRegional deposition tables, flow visualisations and a methods note you can share internally.
→ PDF report and data filesA first, bounded study to test whether simulation answers your question. Price depends on the number of flow rates, particle sizes and whether we use your airway geometry.
Send the device type, target flow rate and particle size. We reply within two working days with a scope and a fixed quote.
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